About Receptor expression-enhancing protein 3
Receptor expression-enhancing protein 3 (REEP3) is a protein
from Homo sapiens identified by UniProt accession
Q6NUK4, 255 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Receptor expression-enhancing protein 3 |
|---|
| UniProt accession | Q6NUK4 |
|---|
| Gene | REEP3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 255 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (148)
Diseases linked to this target (Open Targets).
- body mass index · score 0.37
- alkaline phosphatase measurement · score 0.37
- platelet count · score 0.36
- sex hormone-binding globulin measurement · score 0.34
- diastolic blood pressure · score 0.34
- cholelithiasis · score 0.32
- protein measurement · score 0.31
- mean platelet volume · score 0.30
- body height · score 0.30
- triglyceride measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUK4-F1 | alphafold | PREDICTED | 64.53 | — |
Amino-acid sequence (255 residues)
MVSWMISRAV VLVFGMLYPA YYSYKAVKTK NVKEYVRWMM YWIVFALYTV IETVADQTVA WFPLYYELKI AFVIWLLSPY TKGASLIYRK FLHPLLSSKE REIDDYIVQA KERGYETMVN FGRQGLNLAA TAAVTAAVKS QGAITERLRS FSMHDLTTIQ GDEPVGQRPY QPLPEAKKKS KPAPSESAGY GIPLKDGDEK TDEEAEGPYS DNEMLTHKGL RRSQSMKSVK TTKGRKEVRY GSLKYKVKKR PQVYF
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