About All-trans-retinol 13,14-reductase
All-trans-retinol 13,14-reductase (RETSAT) is a protein
from Homo sapiens identified by UniProt accession
Q6NUM9, 610 residues long.
MolForge cross-references it against 0 known binders and
77 disease associations.
Target properties
| Protein name | All-trans-retinol 13,14-reductase |
|---|
| UniProt accession | Q6NUM9 |
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| Gene | RETSAT |
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| Organism | Homo sapiens |
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| Length | 610 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (77)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.27
- lymphocyte percentage of leukocytes · score 0.19
- neutrophil percentage of leukocytes · score 0.16
- hemoglobin measurement · score 0.12
- bone density · score 0.10
- hematocrit · score 0.10
- urate measurement · score 0.09
- leukocyte count · score 0.07
- neutrophil count · score 0.07
- neoplasm · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUM9-F1 | alphafold | PREDICTED | 95.15 | — |
Amino-acid sequence (610 residues)
MWLPLVLLLA VLLLAVLCKV YLGLFSGSSP NPFSEDVKRP PAPLVTDKEA RKKVLKQAFS ANQVPEKLDV VVIGSGFGGL AAAAILAKAG KRVLVLEQHT KAGGCCHTFG KNGLEFDTGI HYIGRMEEGS IGRFILDQIT EGQLDWAPLS SPFDIMVLEG PNGRKEYPMY SGEKAYIQGL KEKFPQEEAI IDKYIKLVKV VSSGAPHAIL LKFLPLPVVQ LLDRCGLLTR FSPFLQASTQ SLAEVLQQLG ASSELQAVLS YIFPTYGVTP NHSAFSMHAL LVNHYMKGGF YPRGGSSEIA FHTIPVIQRA GGAVLTKATV QSVLLDSAGK ACGVSVKKGH ELVNIYCPIV VSNAGLFNTY EHLLPGNARC LPGVKQQLGT VRPGLGMTSV FICLRGTKED LHLPSTNYYV YYDTDMDQAM ERYVSMPREE AAEHIPLLFF AFPSAKDPTW EDRFPGRSTM IMLIPTAYEW FEEWQAELKG KRGSDYETFK NSFVEASMSV VLKLFPQLEG KVESVTAGSP LTNQFYLAAP RGACYGADHD LGRLHPCVMA SLRAQSPIPN LYLTGQDIFT CGLVGALQGA LLCSSAILKR NLYSDLKNLD SRIRAQKKKN
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