About Serine/threonine-protein phosphatase 4 regulatory subunit 4
Serine/threonine-protein phosphatase 4 regulatory subunit 4 (PPP4R4) is a protein
from Homo sapiens identified by UniProt accession
Q6NUP7, 873 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 4 regulatory subunit 4 |
|---|
| UniProt accession | Q6NUP7 |
|---|
| Gene | PPP4R4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 873 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.32
- neurodegenerative disease · score 0.27
- low density lipoprotein cholesterol measurement · score 0.27
- apolipoprotein B measurement · score 0.21
- total cholesterol measurement · score 0.16
- platelet count · score 0.16
- metabolite measurement · score 0.07
- drug use measurement · score 0.07
- medulloblastoma · score 0.05
- atypical teratoid rhabdoid tumor · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUP7-F1 | alphafold | PREDICTED | 78.40 | — |
Amino-acid sequence (873 residues)
MHPPPPAAAM DFSQNSLFGY MEDLQELTII ERPVRRSLKT PEEIERLTVD EDLSDIERAV YLLSAGQDVQ GTSVIANLPF LMRQNPTETL RRVLPKVREA LHVAGVEMQL TAAMSFLTIL QDESVSIHAY THSFLQVILL HLEHRDTGVS NAWLETLLSV IEVLPKETLR HEILNPLVSK AQLSQTVQSR LVSCKILGKL TNKFDAHTIK REILPLVKSL CQDVEYEVRS CMCRQLENIA QGIGTELTKS VVLPELIELS RDEGSSVRLA AFETLVNLLD IFDTDDRSQT ILPLVKSFCE KSFKADESIL ISLSFHLGKL CHGLYGIFTP DQHLRFLEFY KKLCTLGLQQ ENGHNENQIP PQILEQEKKY ISVRKNCAYN FPAMIVFVDP KNFHMELYST FFCLCHDPEV PVRYTIAICF YEVSKLLNSG VYLIHKELIT LLQDESLEVL DALIDHLPEI LELMSTGGES SVQENKLSSL PDLIPALTAA EQRAAASLKW RTHEKLLQKY ACLPHVISSD QIYYRFLQRM FTIMMTNNVL PVQKAASRTL CIFLRYNRKQ EQRHEVIQKL IEQLGQGKSY WNRLRFLDTC EFIIEIFSKS FFCKYFFLPA IELTHDPVAN VRMKLCYLLP KVKSTLKIPA DKHLLQQLEM CVRKLLCQEK DKDVLAIVKR TVLELDRMEM SMDAFQKKFY EKDLLDQEKE REELLLLEME QLEKEKQQND GRPMSDKMFE KKRRDTKTPT QSLPKNIPIS VPGPSSVTPS TSKEIKKSKL IRSQSFNNQA FHAKYGNLEK CASKSSTTGY TTSVSGLGKT SVLSLADDSF RTRNASSVPS SFSPNTPLPS TSRGTGNSVD PKSSGSKDTQ PRKATLKSRK SNP
Explore Serine/threonine-protein phosphatase 4 regulatory subunit 4 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets