About Probable C-mannosyltransferase DPY19L2
Probable C-mannosyltransferase DPY19L2 (DPY19L2) is a protein
from Homo sapiens identified by UniProt accession
Q6NUT2, 758 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | Probable C-mannosyltransferase DPY19L2 |
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| UniProt accession | Q6NUT2 |
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| Gene | DPY19L2 |
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| Organism | Homo sapiens |
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| Length | 758 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (118)
Diseases linked to this target (Open Targets).
- male infertility due to globozoospermia · score 0.60
- neurodegenerative disease · score 0.22
- genetic disorder · score 0.19
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- partial chromosome Y deletion · score 0.07
- spinocerebellar ataxia type 32 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- isochromosomy Yp · score 0.06
- Isolated follicle stimulating hormone deficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUT2-F1 | alphafold | PREDICTED | 81.40 | — |
Amino-acid sequence (758 residues)
MRKQGVSSKR LQSSGRSQSK GRRGASLARE PEVEEEMEKS ALGGGKLPRG SWRSSPGRIQ SLKERKGLEL EVVAKTFLLG PFQFVRNSLA QLREKVQELQ ARRFSSRTTL GIAVFVAILH WLHLVTLFEN DRHFSHLSSL EREMTFRTEM GLYYSYFKTI IEAPSFLEGL WMIMNDRLTE YPLIINAIKR FHLYPEVIIA SWYCTFMGIM NLFGLETKTC WNVTRIEPLN EVQSCEGLGD PACFYVGVIF ILNGLMMGLF FMYGAYLSGT QLGGLITVLC FFFNHGEATR VMWTPPLRES FSYPFLVLQM CILTLILRTS SNDRRPFIAL CLSNVAFMLP WQFAQFILFT QIASLFPMYV VGYIEPSKFQ KIIYMNMISV TLSFILMFGN SMYLSSYYSS SLLMTWAIIL KRNEIQKLGV SKLNFWLIQG SAWWCGTIIL KFLTSKILGV SDHIRLSDLI AARILRYTDF DTLIYTCAPE FDFMEKATPL RYTKTLLLPV VMVITCFIFK KTVRDISYVL ATNIYLRKQL LEHSELAFHT LQLLVFTALA ILIMRLKMFL TPHMCVMASL ICSRQLFGWL FRRVRFEKVI FGILTVMSIQ GYANLRNQWS IIGEFNNLPQ EELLQWIKYS TTSDAVFAGA MPTMASIKLS TLHPIVNHPH YEDADLRART KIVYSTYSRK SAKEVRDKLL ELHVNYYVLE EAWCVVRTKP GCSMLEIWDV EDPSNAANPP LCSVLLEDAR PYFTTVFQNS VYRVLKVN
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