About Major facilitator superfamily domain-containing protein 12
Major facilitator superfamily domain-containing protein 12 (MFSD12) is a protein
from Homo sapiens identified by UniProt accession
Q6NUT3, 480 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Major facilitator superfamily domain-containing protein 12 |
|---|
| UniProt accession | Q6NUT3 |
|---|
| Gene | MFSD12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 480 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- skin pigmentation measurement · score 0.30
- hair color · score 0.29
- blood protein measurement · score 0.29
- facial pigmentation measurement · score 0.26
- aspartate aminotransferase measurement · score 0.22
- uric acid measurement · score 0.21
- cutaneous melanoma · score 0.20
- eosinophil percentage of leukocytes · score 0.13
- Red cell distribution width · score 0.08
- Griscelli syndrome type 3 · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NUT3-F1 | alphafold | PREDICTED | 84.74 | — |
Amino-acid sequence (480 residues)
MGPGPPAAGA APSPRPLSLV ARLSYAVGHF LNDLCASMWF TYLLLYLHSV RAYSSRGAGL LLLLGQVADG LCTPLVGYEA DRAASCCARY GPRKAWHLVG TVCVLLSFPF IFSPCLGCGA ATPEWAALLY YGPFIVIFQF GWASTQISHL SLIPELVTND HEKVELTALR YAFTVVANIT VYGAAWLLLH LQGSSRVEPT QDISISDQLG GQDVPVFRNL SLLVVGVGAV FSLLFHLGTR ERRRPHAEEP GEHTPLLAPA TAQPLLLWKH WLREPAFYQV GILYMTTRLI VNLSQTYMAM YLTYSLHLPK KFIATIPLVM YLSGFLSSFL MKPINKCIGR NMTYFSGLLV ILAFAAWVAL AEGLGVAVYA AAVLLGAGCA TILVTSLAMT ADLIGPHTNS GAFVYGSMSF LDKVANGLAV MAIQSLHPCP SELCCRACVS FYHWAMVAVT GGVGVAAALC LCSLLLWPTR LRRWDRDARP
Explore Major facilitator superfamily domain-containing protein 12 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets