About Histone H3.3C
Histone H3.3C (H3-5) is a protein
from Homo sapiens identified by UniProt accession
Q6NXT2, 135 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Histone H3.3C |
|---|
| UniProt accession | Q6NXT2 |
|---|
| Gene | H3-5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 135 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (90)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.30
- insulin like growth factor measurement · score 0.30
- C-reactive protein measurement · score 0.28
- amyotrophic lateral sclerosis · score 0.22
- azoospermia · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failure 61 · score 0.06
- spermatogenic failure 59 · score 0.06
- spermatogenic failure 73 · score 0.06
- spermatogenic failure 74 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NXT2-F1 | alphafold | PREDICTED | 85.69 | — |
Amino-acid sequence (135 residues)
MARTKQTARK STGGKAPRKQ LATKAARKST PSTCGVKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFNT DLRFQSAAVG ALQEASEAYL VGLLEDTNLC AIHAKRVTIM PKDIQLARRI RGERA
Explore Histone H3.3C with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets