About Transmembrane anterior posterior transformation protein 1 homolog
Transmembrane anterior posterior transformation protein 1 homolog (TAPT1) is a protein
from Homo sapiens identified by UniProt accession
Q6NXT6, 567 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | Transmembrane anterior posterior transformation protein 1 homolog |
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| UniProt accession | Q6NXT6 |
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| Gene | TAPT1 |
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| Organism | Homo sapiens |
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| Length | 567 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (114)
Diseases linked to this target (Open Targets).
- complex lethal osteochondrodysplasia · score 0.66
- osteochondrodysplasia · score 0.62
- osteogenesis imperfecta · score 0.37
- self reported educational attainment · score 0.20
- genetic disorder · score 0.19
- mathematical ability · score 0.17
- cognitive function measurement · score 0.16
- verbal-numerical reasoning measurement · score 0.16
- intelligence · score 0.13
- scoliosis · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6NXT6-F1 | alphafold | PREDICTED | 71.28 | — |
Amino-acid sequence (567 residues)
MAGVGDAAAP GEGGGGGVDG PQRDGRGEAE QPGGSGGQGP PPAPQLTETL GFYESDRRRE RRRGRTELSL LRFLSAELTR GYFLEHNEAK YTERRERVYT CLRIPRELEK LMVFGIFLCL DAFLYVFTLL PLRVFLALFR LLTLPCYGLR DRRLLQPAQV CDILKGVILV ICYFMMHYVD YSMMYHLIRG QSVIKLYIIY NMLEVADRLF SSFGQDILDA LYWTATEPKE RKRAHIGVIP HFFMAVLYVF LHAILIMVQA TTLNVAFNSH NKSLLTIMMS NNFVEIKGSV FKKFEKNNLF QMSNSDIKER FTNYVLLLIV CLRNMEQFSW NPDHLWVLFP DVCMVIASEI AVDIVKHAFI TKFNDITADV YSEYRASLAF DLVSSRQKNA YTDYSDSVAR RMGFIPLPLA VLLIRVVTSS IKVQGILSYA CVILFYFGLI SLKVLNSIVL LGKSCQYVKE AKMEEKLSNP PATCTPGKPS SKSQNKCKPS QGLSTEENLS ASITKQPIHQ KENIIPLLVT SNSDQFLTTP DGDEKDITQD NSELKHRSSK KDLLEIDRFT ICGNRID
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