Uncharacterized protein C8orf74 (C8orf74)

About Uncharacterized protein C8orf74

Uncharacterized protein C8orf74 (C8orf74) is a protein from Homo sapiens identified by UniProt accession Q6P047, 294 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Uncharacterized protein C8orf74
UniProt accession	Q6P047
Gene	C8orf74
Organism	Homo sapiens
Length	294 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.28
neurodegenerative disease · score 0.22
heart rate response to exercise · score 0.13
platelet component distribution width · score 0.12
alcohol drinking · score 0.12
systolic blood pressure · score 0.12
alcohol consumption measurement · score 0.12
mean arterial pressure · score 0.12
leukocyte count · score 0.10
neutrophil count · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P047-F1	alphafold	PREDICTED	85.14	—

Amino-acid sequence (294 residues)

MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE SIIFAVGKGF PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG HFNTTHLLAL CDYFHHTFIR HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA DVLLLKEALR LERENSLQKA FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ IQNTFAILDL KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards