About F-box and leucine-rich protein 22
F-box and leucine-rich protein 22 (FBXL22) is a protein
from Homo sapiens identified by UniProt accession
Q6P050, 231 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | F-box and leucine-rich protein 22 |
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| UniProt accession | Q6P050 |
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| Gene | FBXL22 |
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| Organism | Homo sapiens |
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| Length | 231 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- FEV/FVC ratio · score 0.38
- refractive error measurement · score 0.29
- HbA1c measurement · score 0.27
- sex hormone-binding globulin measurement · score 0.27
- type 2 diabetes mellitus · score 0.26
- BMI-adjusted waist-hip ratio · score 0.26
- smoking status measurement · score 0.25
- glucose measurement · score 0.25
- electrocardiography · score 0.24
- aortic root size · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P050-F1 | alphafold | PREDICTED | 59.60 | — |
Amino-acid sequence (231 residues)
MWPLLTMHIT QLNRECLLHL FSFLDKDSRK SLARTCSQLH DVFEDPALWS LLHFRSLTEL QKDNFLLGPA LRSLSICWHS SRVQVCSIED WLKSAFQRSI CSRHESLVND FLLRVCDRCP NLASVTLSGC GHVTDDCLAR LLRCCPRLRA LRLENCARVT NRTLAAVAAD GRALQTLHVD FCRNVSAAGL RRLRAACPRL ALRAEHSAAM LPDQPPRPRA PAAALGKLLQ R
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