About Mitochondrial mRNA pseudouridine synthase RPUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3 (RPUSD3) is a protein
from Homo sapiens identified by UniProt accession
Q6P087, 351 residues long.
MolForge cross-references it against 0 known binders and
7 disease associations.
Target properties
| Protein name | Mitochondrial mRNA pseudouridine synthase RPUSD3 |
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| UniProt accession | Q6P087 |
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| Gene | RPUSD3 |
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| Organism | Homo sapiens |
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| Length | 351 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (7)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- genetic disorder · score 0.33
- hepatocellular carcinoma · score 0.02
- glioblastoma multiforme · score 0.01
- neoplasm · score 0.01
- prostate adenocarcinoma · score 0.01
- Sepsis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P087-F1 | alphafold | PREDICTED | 83.51 | — |
Amino-acid sequence (351 residues)
MRAVLAREMD GRRVLGRFWS GWRRGLGVRP VPEDAGFGTE ARHQRQPRGS CQRSGPLGDQ PFAGLLPKNL SREELVDALR AAVVDRKGPL VTLNKPQGLP VTGKPGELTL FSVLPELSQS LGLREQELQV VRASGKESSG LVLLSSCPQT ASRLQKYFTH ARRAQRPTAT YCAVTDGIPA ASEGKIQAAL KLEHIDGVNL TVPVKAPSRK DILEGVKKTL SHFRVVATGS GCALVQLQPL TVFSSQLQVH MVLQLCPVLG DHMYSARVGT VLGQRFLLPA ENNKPQRQVL DEALLRRLHL TPSQAAQLPL HLHLHRLLLP GTRARDTPVE LLAPLPPYFS RTLQCLGLRL Q
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