Large ribosomal subunit protein mL54 (MRPL54)

About Large ribosomal subunit protein mL54

Large ribosomal subunit protein mL54 (MRPL54) is a protein from Homo sapiens identified by UniProt accession Q6P161, 138 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	Large ribosomal subunit protein mL54
UniProt accession	Q6P161
Gene	MRPL54
Organism	Homo sapiens
Length	138 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

melorheostosis · score 0.06
dacryocystitis-osteopoikilosis syndrome · score 0.06
12q14 microdeletion syndrome · score 0.06
Osteoporosis · score 0.05
osteoporosis · score 0.05
pyknoachondrogenesis · score 0.05
Dacryocystitis - osteopoikilosis · score 0.05
osteomesopyknosis · score 0.05
gnathodiaphyseal dysplasia · score 0.04
autosomal recessive hypophosphatemic rickets · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P161-F1	alphafold	PREDICTED	73.00	—

Amino-acid sequence (138 residues)

MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPDA EYPEWLFEMN LGPPKTLEEL DPESREYWRR LRKQNIWRHN RLSKNKRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards