About Polyamine-modulated factor 1
Polyamine-modulated factor 1 (PMF1) is a protein
from Homo sapiens identified by UniProt accession
Q6P1K2, 205 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Polyamine-modulated factor 1 |
|---|
| UniProt accession | Q6P1K2 |
|---|
| Gene | PMF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 205 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- creatinine measurement · score 0.21
- glomerular filtration rate · score 0.19
- Testicular Germ Cell Tumor · score 0.15
- cystatin C measurement · score 0.15
- Ischemic stroke · score 0.15
- mosaic loss of chromosome Y measurement · score 0.15
- stroke · score 0.14
- non-lobar intracerebral hemorrhage · score 0.13
- serum urea measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P1K2-F1 | alphafold | PREDICTED | 87.40 | — |
Amino-acid sequence (205 residues)
MAEASSANLG SGCEEKRHEG SSSESVPPGT TISRVKLLDT MVDTFLQKLV AAGSYQRFTD CYKCFYQLQP AMTQQIYDKF IAQLQTSIRE EISDIKEEGN LEAVLNALDK IVEEGKVRKE PAWRPSGIPE KDLHSVMAPY FLQQRDTLRR HVQKQEAENQ QLADAVLAGR RQVEELQLQV QAQQQAWQAL HREQRELVAV LREPE
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