About Calcium/calmodulin-dependent protein kinase type 1B
Calcium/calmodulin-dependent protein kinase type 1B (PNCK) is a protein
from Homo sapiens identified by UniProt accession
Q6P2M8, 343 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Calcium/calmodulin-dependent protein kinase type 1B |
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| UniProt accession | Q6P2M8 |
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| Gene | PNCK |
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| Organism | Homo sapiens |
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| Length | 343 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- creatine transporter deficiency · score 0.55
- X-linked creatine transporter deficiency · score 0.55
- genetic disorder · score 0.17
- cerebral creatine deficiency syndrome · score 0.16
- nonpapillary renal cell carcinoma · score 0.08
- renal cell carcinoma · score 0.07
- neoplasm · score 0.05
- attention deficit hyperactivity disorder · score 0.04
- hepatocellular carcinoma · score 0.04
- non-small cell lung carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P2M8-F1 | alphafold | PREDICTED | 81.82 | — |
Amino-acid sequence (343 residues)
MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA LRGKEALVEN EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS ESAKDFIRHL LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW
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