Uncharacterized protein C16orf46 (C16orf46)

About Uncharacterized protein C16orf46

Uncharacterized protein C16orf46 (C16orf46) is a protein from Homo sapiens identified by UniProt accession Q6P387, 395 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Uncharacterized protein C16orf46
UniProt accession	Q6P387
Gene	C16orf46
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

mosaic loss of chromosome Y measurement · score 0.21
neurodegenerative disease · score 0.21
glycine measurement · score 0.15
age at onset · score 0.11
Myopia · score 0.11
serum metabolite measurement · score 0.11
mean corpuscular hemoglobin · score 0.10
Romano-Ward syndrome · score 0.06
Familial short QT syndrome · score 0.06
Brugada syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P387-F1	alphafold	PREDICTED	49.84	—

Amino-acid sequence (395 residues)

MDLCQKNETD LENAENNEIQ FTEETEPTYT CPDGKSEKNH VYCLLDVSDI TLEQDEKAKE FIIGTGWEEA VQGWGRTSPA ACIWPRKIPK KARVGEGACS DCLVCVNLSH WSLQTKPPTE GGPEKDQSSP SQTQAAPQGP STASRAISDI CFPTYFRAEK KSLQIKEFIW CNKDWAIPGT NRGKASGNPS GGAHRGLSIP GPLTSRALLV LPPLKASLSN ALDVLGKKSK NSFLQSEEKV LDVEKDGCVA YAYGLKTADG KGEKRASELA KHPMVNDTPS SPSPAAQISL LTDPEQRCLH WSLLSEKNLA CPPDPSNVRY LAALQLLQKR GVQSYKSKFK AKEPRSPVIT RKHVLPKAKQ ENRPQMLETK VFPRPVLPSL TVSRVIIPVS THRIL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards