NIPA-like protein 3 (NIPAL3)

About NIPA-like protein 3

NIPA-like protein 3 (NIPAL3) is a protein from Homo sapiens identified by UniProt accession Q6P499, 406 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	NIPA-like protein 3
UniProt accession	Q6P499
Gene	NIPAL3
Organism	Homo sapiens
Length	406 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

hair colour measurement · score 0.18
hair color · score 0.18
cutaneous melanoma · score 0.17
Neurodevelopmental disorder · score 0.12
skin disease · score 0.09
metabolite measurement · score 0.05
isolated agammaglobulinemia · score 0.05
common variable immunodeficiency · score 0.05
immunodeficiency 18 · score 0.05
classic Hodgkin lymphoma · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P499-F1	alphafold	PREDICTED	75.14	—

Amino-acid sequence (406 residues)

MDGSHSAALK LQQLPPTSSS SAVSEASFSY KENLIGALLA IFGHLVVSIA LNLQKYCHIR LAGSKDPRAY FKTKTWWLGL FLMLLGELGV FASYAFAPLS LIVPLSAVSV IASAIIGIIF IKEKWKPKDF LRRYVLSFVG CGLAVVGTYL LVTFAPNSHE KMTGENVTRH LVSWPFLLYM LVEIILFCLL LYFYKEKNAN NIVVILLLVA LLGSMTVVTV KAVAGMLVLS IQGNLQLDYP IFYVMFVCMV ATAVYQAAFL SQASQMYDSS LIASVGYILS TTIAITAGAI FYLDFIGEDV LHICMFALGC LIAFLGVFLI TRNRKKPIPF EPYISMDAMP GMQNMHDKGM TVQPELKASF SYGALENNDN ISEIYAPATL PVMQEEHGSR SASGVPYRVL EHTKKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards