GDP-fucose protein O-fucosyltransferase 3 (POFUT3)

About GDP-fucose protein O-fucosyltransferase 3

GDP-fucose protein O-fucosyltransferase 3 (POFUT3) is a protein from Homo sapiens identified by UniProt accession Q6P4F1, 479 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	GDP-fucose protein O-fucosyltransferase 3
UniProt accession	Q6P4F1
Gene	POFUT3
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

protein measurement · score 0.31
blood protein measurement · score 0.30
vital capacity · score 0.28
pulse pressure measurement · score 0.27
sleep duration · score 0.25
low density lipoprotein cholesterol measurement · score 0.25
obesity · score 0.23
chronotype measurement · score 0.08
response to vaccine · score 0.06
alcohol consumption measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P4F1-F1	alphafold	PREDICTED	87.92	—

Amino-acid sequence (479 residues)

MVRIQRRKLL ASCLCVTATV FLLVTLQVMV ELGKFERKEF KSSSLQDGHT KMEEAPTHLN SFLKKEGLTF NRKRKWELDS YPIMLWWSPL TGETGRLGQC GADACFFTIN RTYLHHHMTK AFLFYGTDFN IDSLPLPRKA HHDWAVFHEE SPKNNYKLFH KPVITLFNYT ATFSRHSHLP LTTQYLESIE VLKSLRYLVP LQSKNKLRKR LAPLVYVQSD CDPPSDRDSY VRELMTYIEV DSYGECLRNK DLPQQLKNPA SMDADGFYRI IAQYKFILAF ENAVCDDYIT EKFWRPLKLG VVPVYYGSPS ITDWLPSNKS AILVSEFSHP RELASYIRRL DSDDRLYEAY VEWKLKGEIS NQRLLTALRE RKWGVQDVNQ DNYIDAFECM VCTKVWANIR LQEKGLPPKR WEAEDTHLSC PEPTVFAFSP LRTPPLSSLR EMWISSFEQS KKEAQALRWL VDRNQNFSSQ EFWGLVFKD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards