Ferredoxin-2, mitochondrial (FDX2)

About Ferredoxin-2, mitochondrial

Ferredoxin-2, mitochondrial (FDX2) is a protein from Homo sapiens identified by UniProt accession Q6P4F2, 183 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.

Target properties

Protein name	Ferredoxin-2, mitochondrial
UniProt accession	Q6P4F2
Gene	FDX2
Organism	Homo sapiens
Length	183 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (129)

Diseases linked to this target (Open Targets).

Mitochondrial myopathy · score 0.75
congenital adrenal hyperplasia · score 0.37
inborn mitochondrial myopathy · score 0.30
genetic disorder · score 0.27
COVID-19 · score 0.11
FEV/FVC ratio · score 0.09
sclerosing cholangitis · score 0.07
Crohn's disease · score 0.07
psoriasis · score 0.07
ulcerative colitis · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P4F2-F1	alphafold	PREDICTED	76.59	—

Amino-acid sequence (183 residues)

MAASMARGGV SARVLLQAAR GTWWNRPGGT SGSGEGVALG TTRKFQATGS RPAGEEDAGG PERPGDVVNV VFVDRSGQRI PVSGRVGDNV LHLAQRHGVD LEGACEASLA CSTCHVYVSE DHLDLLPPPE EREDDMLDMA PLLQENSRLG CQIVLTPELE GAEFTLPKIT RNFYVDGHVP KPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards