Mitotic-spindle organizing protein 2A (MZT2A)

About Mitotic-spindle organizing protein 2A

Mitotic-spindle organizing protein 2A (MZT2A) is a protein from Homo sapiens identified by UniProt accession Q6P582, 158 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	Mitotic-spindle organizing protein 2A
UniProt accession	Q6P582
Gene	MZT2A
Organism	Homo sapiens
Length	158 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

arterial stiffness measurement · score 0.22
adolescent idiopathic scoliosis · score 0.09
non-small cell lung carcinoma · score 0.08
neoplasm · score 0.02
clear cell renal carcinoma · score 0.01
cancer · score 0.01
lung adenocarcinoma · score 0.01
Alzheimer disease · score 0.01
lymph node metastatic carcinoma · score 0.00
astrocytoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P582-F1	alphafold	PREDICTED	65.08	—

Amino-acid sequence (158 residues)

MAAQGVGPGP GSAAPPGLEA ARQKLALRRK KVLSTEEMEL YELAQAAGGG IDPDVFKILV DLLKLNVAPL AVFQMLKSMC AGQRLASEPQ DPAAVSLPTS SVPETRGRDK GSAALGGVLA LAERSNHEGS SQRMPRQPSA TRLPKGGGPG KSPTQGST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards