About Tumor necrosis factor alpha-induced protein 8-like protein 2
Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) is a protein
from Homo sapiens identified by UniProt accession
Q6P589, 184 residues long.
MolForge cross-references it against 0 known binders and
383 disease associations.
Target properties
| Protein name | Tumor necrosis factor alpha-induced protein 8-like protein 2 |
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| UniProt accession | Q6P589 |
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| Gene | TNFAIP8L2 |
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| Organism | Homo sapiens |
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| Length | 184 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (383)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.20
- eosinophil count · score 0.20
- eosinophil percentage of leukocytes · score 0.13
- neoplasm · score 0.12
- hepatocellular carcinoma · score 0.11
- chronic hepatitis B virus infection · score 0.09
- non-small cell lung carcinoma · score 0.09
- Autoimmune Hepatitis · score 0.08
- gonorrhea · score 0.08
- Rheumatoid arthritis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P589-F1 | alphafold | PREDICTED | 90.36 | — |
Amino-acid sequence (184 residues)
MESFSSKSLA LQAEKKLLSK MAGRSVAHLF IDETSSEVLD ELYRVSKEYT HSRPQAQRVI KDLIKVAIKV AVLHRNGSFG PSELALATRF RQKLRQGAMT ALSFGEVDFT FEAAVLAGLL TECRDVLLEL VEHHLTPKSH GRIRHVFDHF SDPGLLTALY GPDFTQHLGK ICDGLRKLLD EGKL
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