Kinesin light chain 3 (KLC3)

About Kinesin light chain 3

Kinesin light chain 3 (KLC3) is a protein from Homo sapiens identified by UniProt accession Q6P597, 504 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Kinesin light chain 3
UniProt accession	Q6P597
Gene	KLC3
Organism	Homo sapiens
Length	504 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

monocyte count · score 0.24
ovarian cancer · score 0.18
breast adenocarcinoma · score 0.18
Xeroderma pigmentosum complementation group D · score 0.18
leukocyte count · score 0.15
glioblastoma multiforme · score 0.15
neutrophil count · score 0.13
xeroderma pigmentosum · score 0.12
medulloblastoma · score 0.10
isolated asymptomatic elevation of creatine phosphokinase · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P597-F1	alphafold	PREDICTED	74.86	—

Amino-acid sequence (504 residues)

MSVQVAAPGS AGLGPERLSP EELVRQTRQV VQGLEALRAE HHGLAGHLAE ALAGQGPAAG LEMLEEKQQV VSHSLEAIEL GLGEAQVLLA LSAHVGALEA EKQRLRSQAR RLAQENVWLR EELEETQRRL RASEESVAQL EEEKRHLEFL GQLRQYDPPA ESQQSESPPR RDSLASLFPS EEEERKGPEA AGAAAAQQGG YEIPARLRTL HNLVIQYAGQ GRYEVAVPLC RQALEDLERS SGHCHPDVAT MLNILALVYR DQNKYKEATD LLHDALQIRE QTLGPEHPAV AATLNNLAVL YGKRGRYREA EPLCQRALEI REKVLGADHP DVAKQLNNLA LLCQNQGKFE DVERHYARAL SIYEALGGPH DPNVAKTKNN LASAYLKQNK YQQAEELYKE ILHKEDLPAP LGAPNTGTAG DAEQALRRSS SLSKIRESIR RGSEKLVSRL RGEAAAGAAG MKRAMSLNTL NVDAPRAPGT QFPSWHLDKA PRTLSASTQD LSPH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards