RNA demethylase ALKBH5 (ALKBH5)

About RNA demethylase ALKBH5

RNA demethylase ALKBH5 (ALKBH5) is a protein from Homo sapiens identified by UniProt accession Q6P6C2, 394 residues long. MolForge cross-references it against 0 known binders and 365 disease associations.

Target properties

Protein name	RNA demethylase ALKBH5
UniProt accession	Q6P6C2
Gene	ALKBH5
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (365)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
platelet count · score 0.27
calcium measurement · score 0.25
hematocrit · score 0.25
hemoglobin measurement · score 0.23
breast adenocarcinoma · score 0.18
total cholesterol measurement · score 0.17
apolipoprotein B measurement · score 0.17
low density lipoprotein cholesterol measurement · score 0.16
serum albumin measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6P6C2-F1	alphafold	PREDICTED	72.22	—

Amino-acid sequence (394 residues)

MAAASGYTDL REKLKSMTSR DNYKAGSREA AAAAAAAVAA AAAAAAAAEP YPVSGAKRKY QEDSDPERSD YEEQQLQKEE EARKVKSGIR QMRLFSQDEC AKIEARIDEV VSRAEKGLYN EHTVDRAPLR NKYFFGEGYT YGAQLQKRGP GQERLYPPGD VDEIPEWVHQ LVIQKLVEHR VIPEGFVNSA VINDYQPGGC IVSHVDPIHI FERPIVSVSF FSDSALCFGC KFQFKPIRVS EPVLSLPVRR GSVTVLSGYA ADEITHCIRP QDIKERRAVI ILRKTRLDAP RLETKSLSSS VLPPSYASDR LSGNNRDPAL KPKRSHRKAD PDAAHRPRIL EMDKEENRRS VLLPTHRRRG SFSSENYWRK SYESSEDCSE AAGSPARKVK MRRH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards