About Palmitoleoyl-protein carboxylesterase NOTUM
Palmitoleoyl-protein carboxylesterase NOTUM (NOTUM) is a protein
from Homo sapiens identified by UniProt accession
Q6P988, 496 residues long.
MolForge cross-references it against 0 known binders and
219 disease associations.
Target properties
| Protein name | Palmitoleoyl-protein carboxylesterase NOTUM |
|---|
| UniProt accession | Q6P988 |
|---|
| Gene | NOTUM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 496 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (219)
Diseases linked to this target (Open Targets).
- hair color · score 0.23
- waist-hip ratio · score 0.21
- erythrocyte count · score 0.21
- blood protein measurement · score 0.17
- BMI-adjusted waist-hip ratio · score 0.16
- peak expiratory flow · score 0.16
- forced expiratory volume · score 0.15
- refractive error measurement · score 0.14
- vital capacity · score 0.09
- neoplasm · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P988-F1 | alphafold | PREDICTED | 83.93 | — |
Amino-acid sequence (496 residues)
MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE SFPLDFTAVE GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT CNDGSPAGYY LKESRGSRRW LLFLEGGWYC FNRENCDSRY DTMRRLMSSR DWPRTRTGTG ILSSQPEENP YWWNANMVFI PYCSSDVWSG ASSKSEKNEY AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL NVDRVAEQLE KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGIRYWNG VVPERCRRQF QEGEEWNCFF GYKVYPTLRC PVFVVQWLFD EAQLTVDNVH LTGQPVQEGL RLYIQNLGRE LRHTLKDVPA SFAPACLSHE IIIRSHWTDV QVKGTSLPRA LHCWDRSLHD SHKASKTPLK GCPVHLVDSC PWPHCNPSCP TVRDQFTGQE MNVAQFLMHM GFDMQTVAQP QGLEPSELLG MLSNGS
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