About Polypeptide N-acetylgalactosaminyltransferase 18
Polypeptide N-acetylgalactosaminyltransferase 18 (GALNT18) is a protein
from Homo sapiens identified by UniProt accession
Q6P9A2, 607 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Polypeptide N-acetylgalactosaminyltransferase 18 |
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| UniProt accession | Q6P9A2 |
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| Gene | GALNT18 |
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| Organism | Homo sapiens |
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| Length | 607 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.38
- Okur-Chung neurodevelopmental syndrome · score 0.27
- metabolite measurement · score 0.26
- body mass index · score 0.26
- blood phosphate measurement · score 0.19
- bone density · score 0.18
- urate measurement · score 0.18
- diastolic blood pressure · score 0.14
- glioblastoma multiforme · score 0.13
- skin pigmentation measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P9A2-F1 | alphafold | PREDICTED | 88.77 | — |
Amino-acid sequence (607 residues)
MVCTRKTKTL VSTCVILSGM TNIICLLYVG WVTNYIASVY VRGQEPAPDK KLEEDKGDTL KIIERLDHLE NVIKQHIQEA PAKPEEAEAE PFTDSSLFAH WGQELSPEGR RVALKQFQYY GYNAYLSDRL PLDRPLPDLR PSGCRNLSFP DSLPEVSIVF IFVNEALSVL LRSIHSAMER TPPHLLKEII LVDDNSSNEE LKEKLTEYVD KVNSQKPGFI KVVRHSKQEG LIRSRVSGWR AATAPVVALF DAHVEFNVGW AEPVLTRIKE NRKRIISPSF DNIKYDNFEI EEYPLAAQGF DWELWCRYLN PPKAWWKLEN STAPIRSPAL IGCFIVDRQY FQEIGLLDEG MEVYGGENVE LGIRVWQCGG SVEVLPCSRI AHIERAHKPY TEDLTAHVRR NALRVAEVWM DEFKSHVYMA WNIPQEDSGI DIGDITARKA LRKQLQCKTF RWYLVSVYPE MRMYSDIIAY GVLQNSLKTD LCLDQGPDTE NVPIMYICHG MTPQNVYYTS SQQIHVGILS PTVDDDDNRC LVDVNSRPRL IECSYAKAKR MKLHWQFSQG GPIQNRKSKR CLELQENSDL EFGFQLVLQK CSGQHWSITN VLRSLAS
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