About Integrator complex subunit 5
Integrator complex subunit 5 (INTS5) is a protein
from Homo sapiens identified by UniProt accession
Q6P9B9, 1019 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Integrator complex subunit 5 |
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| UniProt accession | Q6P9B9 |
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| Gene | INTS5 |
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| Organism | Homo sapiens |
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| Length | 1019 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- polycystic kidney disease 3 with or without polycystic liver disease · score 0.33
- kidney disease · score 0.33
- mean corpuscular hemoglobin concentration · score 0.06
- blood protein measurement · score 0.03
- resting heart rate · score 0.03
- triglyceride measurement · score 0.02
- diet measurement · score 0.02
- forced expiratory volume · score 0.02
- vital capacity · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P9B9-F1 | alphafold | PREDICTED | 77.13 | — |
Amino-acid sequence (1019 residues)
MSALCDPPGA PGPPGPAPAT HGPAPLSAQE LSQEIKAFLT GVDPILGHQL SAREHARCGL LLLRSLPPAR AAVLDHLRGV FDESVRAHLA ALDETPVAGP PHLRPPPPSH VPAGGPGLED VVQEVQQVLS EFIRANPKAW APVISAWSID LMGQLSSTYS GQHQRVPHAT GALNELLQLW MGCRATRTLM DIYVQCLSAL IGSCPDACVD ALLDTSVQHS PHFDWVVAHI GSSFPGTIIS RVLSCGLKDF CVHGGAGGGA GSSGGSSSQT PSTDPFPGSP AIPAEKRVPK IASVVGILGH LASRHGDSIR RELLRMFHDS LAGGSGGRSG DPSLQATVPF LLQLAVMSPA LLGTVSGELV DCLKPPAVLS QLQQHLQGFP REELDNMLNL AVHLVSQASG AGAYRLLQFL VDTAMPASVI TTQGLAVPDT VREACDRLIQ LLLLHLQKLV HHRGGSPGEG VLGPPPPPRL VPFLDALKNH VGELCGETLR LERKRFLWQH QLLGLLSVYT RPSCGPEALG HLLSRARSPE ELSLATQLYA GLVVSLSGLL PLAFRSCLAR VHAGTLQPPF TARFLRNLAL LVGWEQQGGE GPAALGAHFG ESASAHLSDL APLLLHPEEE VAEAAASLLA ICPFPSEALS PSQLLGLVRA GVHRFFASLR LHGPPGVASA CQLLTRLSQT SPAGLKAVLQ LLVEGALHRG NTELFGGQVD GDNETLSVVS ASLASASLLD TNRRHTAAVP GPGGIWSVFH AGVIGRGLKP PKFVQSRNQQ EVIYNTQSLL SLLVHCCSAP GGTECGECWG APILSPEAAK AVAVTLVESV CPDAAGAELA WPPEEHARAT VERDLRIGRR FREQPLLFEL LKLVAAAPPA LCYCSVLLRG LLAALLGHWE ASRHPDTTHS PWHLEASCTL VAVMAEGSLL PPALGNMHEV FSQLAPFEVR LLLLSVWGFL REHGPLPQKF IFQSERGRFI RDFSREGGGE GGPHLAVLHS VLHRNIDRLG LFSGRFQAPS PSTLLRQGT
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