About E3 ubiquitin ligase TRIM40
E3 ubiquitin ligase TRIM40 (TRIM40) is a protein
from Homo sapiens identified by UniProt accession
Q6P9F5, 258 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | E3 ubiquitin ligase TRIM40 |
|---|
| UniProt accession | Q6P9F5 |
|---|
| Gene | TRIM40 |
|---|
| Organism | Homo sapiens |
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| Length | 258 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (56)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.55
- reticulocyte measurement · score 0.55
- Immature Reticulocyte Fraction Measurement · score 0.46
- sitting height measurement · score 0.30
- body height · score 0.24
- Parkinson disease · score 0.19
- lymphocyte count · score 0.17
- neuritic plaque measurement · score 0.12
- prostate carcinoma · score 0.11
- hip circumference · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P9F5-F1 | alphafold | PREDICTED | 76.16 | — |
Amino-acid sequence (258 residues)
MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV FCCPLCRKPC SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM SHHELTIENA LSHYKERLNR RSRKLRKDIA ELQRLKAQQE KKLQALQFQV DHGNHRLEAG PESQHQTREQ LGALPQQWLG QLEHMPAEAA RILDISRAVT QLRSLVIDLE RTAKELDTNT LKNAGDLLNR SAPQKLEVIY PQLEKGVSEL LLQPPQKL
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