About Volume-regulated anion channel subunit LRRC8B
Volume-regulated anion channel subunit LRRC8B (LRRC8B) is a protein
from Homo sapiens identified by UniProt accession
Q6P9F7, 803 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Volume-regulated anion channel subunit LRRC8B |
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| UniProt accession | Q6P9F7 |
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| Gene | LRRC8B |
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| Organism | Homo sapiens |
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| Length | 803 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.44
- mean platelet volume · score 0.40
- mathematical ability · score 0.34
- blood protein measurement · score 0.30
- total blood protein measurement · score 0.29
- adolescent idiopathic scoliosis · score 0.29
- monocyte percentage of leukocytes · score 0.26
- myxosarcoma · score 0.02
- psoriasis · score 0.01
- oligodendroglioma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P9F7-F1 | alphafold | PREDICTED | 81.01 | — |
Amino-acid sequence (803 residues)
MITLTELKCL ADAQSSYHIL KPWWDVFWYY ITLIMLLVAV LAGALQLTQS RVLCCLPCKV EFDNHCAVPW DILKASMNTS SNPGTPLPLP LRIQNDLHRQ QYSYIDAVCY EKQLHWFAKF FPYLVLLHTL IFAACSNFWL HYPSTSSRLE HFVAILHKCF DSPWTTRALS ETVAEQSVRP LKLSKSKILL SSSGCSADID SGKQSLPYPQ PGLESAGIES PTSSVLDKKE GEQAKAIFEK VKRFRMHVEQ KDIIYRVYLK QIIVKVILFV LIITYVPYFL THITLEIDCS VDVQAFTGYK RYQCVYSLAE IFKVLASFYV ILVILYGLTS SYSLWWMLRS SLKQYSFEAL REKSNYSDIP DVKNDFAFIL HLADQYDPLY SKRFSIFLSE VSENKLKQIN LNNEWTVEKL KSKLVKNAQD KIELHLFMLN GLPDNVFELT EMEVLSLELI PEVKLPSAVS QLVNLKELRV YHSSLVVDHP ALAFLEENLK ILRLKFTEMG KIPRWVFHLK NLKELYLSGC VLPEQLSTMQ LEGFQDLKNL RTLYLKSSLS RIPQVVTDLL PSLQKLSLDN EGSKLVVLNN LKKMVNLKSL ELISCDLERI PHSIFSLNNL HELDLRENNL KTVEEIISFQ HLQNLSCLKL WHNNIAYIPA QIGALSNLEQ LSLDHNNIEN LPLQLFLCTK LHYLDLSYNH LTFIPEEIQY LSNLQYFAVT NNNIEMLPDG LFQCKKLQCL LLGKNSLMNL SPHVGELSNL THLELIGNYL ETLPPELEGC QSLKRNCLIV EENLLNTLPL PVTERLQTCL DKC
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