About Transmembrane protein 154
Transmembrane protein 154 (TMEM154) is a protein
from Homo sapiens identified by UniProt accession
Q6P9G4, 183 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Transmembrane protein 154 |
|---|
| UniProt accession | Q6P9G4 |
|---|
| Gene | TMEM154 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 183 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.44
- type 2 diabetes mellitus · score 0.28
- mean corpuscular hemoglobin concentration · score 0.12
- diabetes mellitus · score 0.08
- Red cell distribution width · score 0.07
- Drugs used in diabetes use measurement · score 0.05
- body height · score 0.04
- eosinophil count · score 0.04
- mean corpuscular volume · score 0.03
- Barrett's esophagus · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6P9G4-F1 | alphafold | PREDICTED | 62.51 | — |
Amino-acid sequence (183 residues)
MQAPRAALVF ALVIALVPVG RGNYEELENS GDTTVESERP NKVTIPSTFA AVTIKETLNA NINSTNFAPD ENQLEFILMV LIPLILLVLL LLSVVFLATY YKRKRTKQEP SSQGSQSALQ TYELGSENVK VPIFEEDTPS VMEIEMEELD KWMNSMNRNA DFECLPTLKE EKESNHNPSD SES
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