About von Willebrand factor A domain-containing protein 1
von Willebrand factor A domain-containing protein 1 (VWA1) is a protein
from Homo sapiens identified by UniProt accession
Q6PCB0, 445 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | von Willebrand factor A domain-containing protein 1 |
|---|
| UniProt accession | Q6PCB0 |
|---|
| Gene | VWA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 445 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (41)
Diseases linked to this target (Open Targets).
- neuronopathy, distal hereditary motor, autosomal recessive 7 · score 0.71
- neuromuscular disease · score 0.39
- neuronopathy, distal hereditary motor, autosomal recessive 5 · score 0.37
- von Willebrand factor measurement · score 0.14
- myocardial infarction · score 0.04
- body height · score 0.04
- craniofacial microsomia · score 0.03
- refractive error measurement · score 0.03
- infection · score 0.02
- infect · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PCB0-F1 | alphafold | PREDICTED | 78.37 | — |
Amino-acid sequence (445 residues)
MLPWTALGLA LSLRLALARS GAERGPPASA PRGDLMFLLD SSASVSHYEF SRVREFVGQL VAPLPLGTGA LRASLVHVGS RPYTEFPFGQ HSSGEAAQDA VRASAQRMGD THTGLALVYA KEQLFAEASG ARPGVPKVLV WVTDGGSSDP VGPPMQELKD LGVTVFIVST GRGNFLELSA AASAPAEKHL HFVDVDDLHI IVQELRGSIL DAMRPQQLHA TEITSSGFRL AWPPLLTADS GYYVLELVPS AQPGAARRQQ LPGNATDWIW AGLDPDTDYD VALVPESNVR LLRPQILRVR TRPGEAGPGA SGPESGAGPA PTQLAALPAP EEAGPERIVI SHARPRSLRV SWAPALGSAA ALGYHVQFGP LRGGEAQRVE VPAGRNCTTL QGLAPGTAYL VTVTAAFRSG RESALSAKAC TPDGPRPRPR PVPRAPTPGT ASREP
Explore von Willebrand factor A domain-containing protein 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets