Alpha/beta hydrolase domain-containing protein 17C…

About Alpha/beta hydrolase domain-containing protein 17C

Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) is a protein from Homo sapiens identified by UniProt accession Q6PCB6, 329 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Alpha/beta hydrolase domain-containing protein 17C
UniProt accession	Q6PCB6
Gene	ABHD17C
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

lean body mass · score 0.51
body mass index · score 0.51
systolic blood pressure · score 0.50
body fat percentage · score 0.49
fat body mass · score 0.48
hypertension · score 0.46
body weight · score 0.43
diastolic blood pressure · score 0.41
Calcium channel blocker use measurement · score 0.41
Diuretic use measurement · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6PCB6-F1	alphafold	PREDICTED	84.55	—

Amino-acid sequence (329 residues)

MPEPGPRMNG FSLGELCWLF CCPPCPSRIA AKLAFLPPEP TYTVLAPEQR GAGASAPAPA QATAAAAAAQ PAPQQPEEGA GAGPGACSLH LSERADWQYS QRELDAVEVF FSRTARDNRL GCMFVRCAPS SRYTLLFSHG NAVDLGQMCS FYIGLGSRIN CNIFSYDYSG YGVSSGKPSE KNLYADIDAA WQALRTRYGV SPENIILYGQ SIGTVPTVDL ASRYECAAVI LHSPLMSGLR VAFPDTRKTY CFDAFPSIDK ISKVTSPVLV IHGTEDEVID FSHGLAMYER CPRAVEPLWV EGAGHNDIEL YAQYLERLKQ FISHELPNS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Alpha/beta hydrolase domain-containing protein 17C (ABHD17C)