About E3 ubiquitin-protein ligase RFWD3
E3 ubiquitin-protein ligase RFWD3 (RFWD3) is a protein
from Homo sapiens identified by UniProt accession
Q6PCD5, 774 residues long.
MolForge cross-references it against 0 known binders and
207 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RFWD3 |
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| UniProt accession | Q6PCD5 |
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| Gene | RFWD3 |
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| Organism | Homo sapiens |
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| Length | 774 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (207)
Diseases linked to this target (Open Targets).
- Fanconi anemia, complementation group W · score 0.53
- Fanconi anemia · score 0.37
- neurodegenerative disease · score 0.37
- mean corpuscular volume · score 0.37
- body fat percentage · score 0.35
- multiple myeloma · score 0.32
- Testicular Germ Cell Tumor · score 0.30
- mean corpuscular hemoglobin · score 0.27
- mean corpuscular hemoglobin concentration · score 0.27
- cystatin C measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PCD5-F1 | alphafold | PREDICTED | 70.10 | — |
Amino-acid sequence (774 residues)
MAHEAMEYDV QVQLNHAEQQ PAPAGMASSQ GGPALLQPVP ADVVSSQGVP SILQPAPAEV ISSQATPPLL QPAPQLSVDL TEVEVLGEDT VENINPRTSE QHRQGSDGNH TIPASSLHSM TNFISGLQRL HGMLEFLRPS SSNHSVGPMR TRRRVSASRR ARAGGSQRTD SARLRAPLDA YFQVSRTQPD LPATTYDSET RNPVSEELQV SSSSDSDSDS SAEYGGVVDQ AEESGAVILE EQLAGVSAEQ EVTCIDGGKT LPKQPSPQKS EPLLPSASMD EEEGDTCTIC LEQWTNAGDH RLSALRCGHL FGYRCISTWL KGQVRKCPQC NKKARHSDIV VLYARTLRAL DTSEQERMKS SLLKEQMLRK QAELESAQCR LQLQVLTDKC TRLQRRVQDL QKLTSHQSQN LQQPRGSQAW VLSCSPSSQG QHKHKYHFQK TFTVSQAGNC RIMAYCDALS CLVISQPSPQ ASFLPGFGVK MLSTANMKSS QYIPMHGKQI RGLAFSSYLR GLLLSASLDN TIKLTSLETN TVVQTYNAGR PVWSCCWCLD EANYIYAGLA NGSILVYDVR NTSSHVQELV AQKARCPLVS LSYMPRAASA AFPYGGVLAG TLEDASFWEQ KMDFSHWPHV LPLEPGGCID FQTENSSRHC LVTYRPDKNH TTIRSVLMEM SYRLDDTGNP ICSCQPVHTF FGGPTCKLLT KNAIFQSPEN DGNILVCTGD EAANSALLWD AASGSLLQDL QTDQPVLDIC PFEVNRNSYL ATLTEKMVHI YKWE
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