About Glucose 1,6-bisphosphate synthase
Glucose 1,6-bisphosphate synthase (PGM2L1) is a protein
from Homo sapiens identified by UniProt accession
Q6PCE3, 622 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Glucose 1,6-bisphosphate synthase |
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| UniProt accession | Q6PCE3 |
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| Gene | PGM2L1 |
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| Organism | Homo sapiens |
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| Length | 622 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- hematocrit · score 0.42
- genetic disorder · score 0.41
- Neurodevelopmental disorder · score 0.37
- mean corpuscular volume · score 0.35
- hemoglobin measurement · score 0.30
- mean corpuscular hemoglobin concentration · score 0.30
- metabolite measurement · score 0.15
- HbA1c measurement · score 0.12
- appendicular lean mass · score 0.11
- atypical teratoid rhabdoid tumor · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PCE3-F1 | alphafold | PREDICTED | 94.40 | — |
Amino-acid sequence (622 residues)
MAENTEGDLN SNLLHAPYHT GDPQLDTAIG QWLRWDKNPK TKEQIENLLR NGMNKELRDR LCCRMTFGTA GLRSAMGAGF CYINDLTVIQ STQGMYKYLE RCFSDFKQRG FVVGYDTRGQ VTSSCSSQRL AKLTAAVLLA KDVPVYLFSR YVPTPFVPYA VQKLKAVAGV MITASHNRKE DNGYKVYWET GAQITSPHDK EILKCIEECV EPWNGSWNDN LVDTSPLKRD PLQDICRRYM EDLKKICFYR ELNSKTTLKF VHTSFHGVGH DYVQLAFKVF GFKPPIPVPE QKDPDPDFST VKCPNPEEGE SVLELSLRLA EKENARVVLA TDPDADRLAA AELQENGCWK VFTGNELAAL FGWWMFDCWK KNKSRNADVK NVYMLATTVS SKILKAIALK EGFHFEETLP GFKWIGSRII DLLENGKEVL FAFEESIGFL CGTSVLDKDG VSAAVVVAEM ASYLETMNIT LKQQLVKVYE KYGYHISKTS YFLCYEPPTI KSIFERLRNF DSPKEYPKFC GTFAILHVRD VTTGYDSSQP NKKSVLPVSK NSQMITFTFQ NGCVATLRTS GTEPKIKYYA EMCASPDQSD TALLEEELKK LIDALIENFL QPSKNGLIWR SV
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