About F-box/LRR-repeat protein 19
F-box/LRR-repeat protein 19 (FBXL19) is a protein
from Homo sapiens identified by UniProt accession
Q6PCT2, 694 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | F-box/LRR-repeat protein 19 |
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| UniProt accession | Q6PCT2 |
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| Gene | FBXL19 |
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| Organism | Homo sapiens |
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| Length | 694 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (151)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- diastolic blood pressure · score 0.26
- total blood protein measurement · score 0.23
- pulse pressure measurement · score 0.20
- clear cell renal carcinoma · score 0.18
- cystatin C measurement · score 0.14
- monocyte count · score 0.14
- Neurodevelopmental delay · score 0.12
- Graves disease · score 0.11
- hepatocellular carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PCT2-F1 | alphafold | PREDICTED | 66.56 | — |
Amino-acid sequence (694 residues)
MGMKVPGKGE SGPSALLTPP MSSSSRGPGA GARRRRTRCR RCRACVRTEC GDCHFCRDMK KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV EGEEEKFGLS LMECTICNEI VHPGCLKMGK AEGVINAEIP NCWECPRCTQ EGRTSKDSGE GPGRRRADNG EEGASLGSGW KLTEEPPLPP PPPRRKGPLP AGPPPEDVPG PPKRKEREAG NEPPTPRKKV KGGRERHLKK VGGDACLLRG SDPGGPGLLP PRVLNPSQAF SSCHPGLPPE NWEKPKPPLA SAEGPAVPSP SPQREKLERF KRMCQLLERV PDTSSSSSDS DSDSDSSGTS LSEDEAPGEA RNGRRPARGS SGEKENRGGR RAVRPGSGGP LLSWPLGPAP PPRPPQLERH VVRPPPRSPE PDTLPLAAGS DHPLPRAAWL RVFQHLGPRE LCICMRVCRT WSRWCYDKRL WPRMDLSRRK SLTPPMLSGV VRRQPRALDL SWTGVSKKQL MWLLNRLQGL QELVLSGCSW LSVSALGSAP LPALRLLDLR WIEDVKDSQL RELLLPPPDT KPGQTESRGR LQGVAELRLA GLELTDASLR LLLRHAPQLS ALDLSHCAHV GDPSVHLLTA PTSPLRETLV HLNLAGCHRL TDHCLPLFRR CPRLRRLDLR SCRQLSPEAC ARLAAAGPPG PFRCPEEKLL LKDS
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