Alpha- and gamma-adaptin-binding protein p34 (AAGAB)

About Alpha- and gamma-adaptin-binding protein p34

Alpha- and gamma-adaptin-binding protein p34 (AAGAB) is a protein from Homo sapiens identified by UniProt accession Q6PD74, 315 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Alpha- and gamma-adaptin-binding protein p34
UniProt accession	Q6PD74
Gene	AAGAB
Organism	Homo sapiens
Length	315 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

punctate palmoplantar keratoderma type 1 · score 0.63
neurodegenerative disease · score 0.50
Palmoplantar keratoderma · score 0.44
eosinophil count · score 0.31
vital capacity · score 0.30
diastolic blood pressure · score 0.28
asthma · score 0.28
BMI-adjusted waist-hip ratio · score 0.23
BMI-adjusted waist circumference · score 0.22
eosinophil percentage of leukocytes · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6PD74-F1	alphafold	PREDICTED	79.66	—

Amino-acid sequence (315 residues)

MAAGVPCALV TSCSSVFSGD QLVQHILGTE DLIVEVTSND AVRFYPWTID NKYYSADINL CVVPNKFLVT AEIAESVQAF VVYFDSTQKS GLDSVSSWLP LAKAWLPEVM ILVCDRVSED GINRQKAQEW CIKHGFELVE LSPEELPEED DDFPESTGVK RIVQALNANV WSNVVMKNDR NQGFSLLNSL TGTNHSIGSA DPCHPEQPHL PAADSTESLS DHRGGASNTT DAQVDSIVDP MLDLDIQELA SLTTGGGDVE NFERLFSKLK EMKDKAATLP HEQRKVHAEK VAKAFWMAIG GDRDEIEGLS SDEEH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards