Inactive serine protease 54 (PRSS54)

About Inactive serine protease 54

Inactive serine protease 54 (PRSS54) is a protein from Homo sapiens identified by UniProt accession Q6PEW0, 395 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Inactive serine protease 54
UniProt accession	Q6PEW0
Gene	PRSS54
Organism	Homo sapiens
Length	395 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (64)

Diseases linked to this target (Open Targets).

azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.08
drug use measurement · score 0.07
partial chromosome Y deletion · score 0.06
spermatogenic failure 20 · score 0.06
spermatogenic failure 72 · score 0.06
spermatogenic failure 46 · score 0.06
spermatogenic failure 27 · score 0.06
spermatogenic failure 18 · score 0.06
spermatogenic failure 42 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6PEW0-F1	alphafold	PREDICTED	67.41	—

Amino-acid sequence (395 residues)

MVSAAGLSGD GKMRGVLLVL LGLLYSSTSC GVQKASVFYG PDPKEGLVSS MEFPWVVSLQ DSQYTHLAFG CILSEFWVLS IASAIQNRKD IVVIVGISNM DPSKIAHTEY PVNTIIIHED FDNNSMSNNI ALLKTDTAMH FGNLVQSICF LGRMLHTPPV LQNCWVSGWN PTSATGNHMT MSVLRKIFVK DLDMCPLYKL QKTECGSHTK EETKTACLGD PGSPMMCQLQ QFDLWVLRGV LNFGGETCPG LFLYTKVEDY SKWITSKAER AGPPLSSLHH WEKLISFSHH GPNATMTQKT YSDSELGHVG SYLQGQRRTI THSRLGNSSR DSLDVREKDV KESGRSPEAS VQPLYYDYYG GEVGEGRIFA GQNRLYQPEE IILVSFVLVF FCSSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards