About Zinc finger CCHC domain-containing protein 12
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) is a protein
from Homo sapiens identified by UniProt accession
Q6PEW1, 402 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Zinc finger CCHC domain-containing protein 12 |
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| UniProt accession | Q6PEW1 |
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| Gene | ZCCHC12 |
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| Organism | Homo sapiens |
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| Length | 402 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- papillary thyroid carcinoma · score 0.09
- type 2 diabetes mellitus · score 0.08
- osteosarcoma · score 0.07
- complication · score 0.06
- neoplasm · score 0.04
- glioblastoma multiforme · score 0.03
- astrocytoma · score 0.02
- oligodendroglioma · score 0.02
- juvenile idiopathic arthritis · score 0.01
- endometrial carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PEW1-F1 | alphafold | PREDICTED | 70.57 | — |
Amino-acid sequence (402 residues)
MASIIARVGN SRRLNAPLPP WAHSMLRSLG RSLGPIMASM ADRNMKLFSG RVVPAQGEET FENWLTQVNG VLPDWNMSEE EKLKRLMKTL RGPAREVMRV LQATNPNLSV ADFLRAMKLV FGESESSVTA HGKFFNTLQA QGEKASLYVI RLEVQLQNAI QAGIIAEKDA NRTRLQQLLL GGELSRDLRL RLKDFLRMYA NEQERLPNFL ELIRMVREEE DWDDAFIKRK RPKRSESMVE RAVSPVAFQG SPPIVIGSAD CNVIEIDDTL DDSDEDVILV ESQDPPLPSW GAPPLRDRAR PQDEVLVIDS PHNSRAQFPS TSGGSGYKNN GPGEMRRARK RKHTIRCSYC GEEGHSKETC DNESDKAQVF ENLIITLQEL THTEMERSRV APGEYNDFSE PL
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