About tRNA methyltransferase 10 homolog B
tRNA methyltransferase 10 homolog B (TRMT10B) is a protein
from Homo sapiens identified by UniProt accession
Q6PF06, 316 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | tRNA methyltransferase 10 homolog B |
|---|
| UniProt accession | Q6PF06 |
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| Gene | TRMT10B |
|---|
| Organism | Homo sapiens |
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| Length | 316 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (9)
Diseases linked to this target (Open Targets).
- reticulocyte measurement · score 0.11
- reticulocyte count · score 0.11
- systolic blood pressure · score 0.05
- hypoparathyroidism, familial isolated, 2 · score 0.04
- pseudohypoparathyroidism type 2 · score 0.03
- PHF-tau measurement · score 0.02
- protein measurement · score 0.02
- lung adenocarcinoma · score 0.00
- chronic myelogenous leukemia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PF06-F1 | alphafold | PREDICTED | 80.09 | — |
Amino-acid sequence (316 residues)
MDWKLEGSTQ KVESPVLQGQ EGILEETGED GLPEGFQLLQ IDAEGECQEG EILATGSTAW CSKNVQRKQR HWEKIVAAKK SKRKQEKERR KANRAENPGI CPQHSKRFLR ALTKDKLLEA KHSGPRLCID LSMTHYMSKK ELSRLAGQIR RLYGSNKKAD RPFWICLTGF TTDSPLYEEC VRMNDGFSSY LLDITEEDCF SLFPLETLVY LTPDSEHALE DVDLNKVYIL GGLVDESIQK KVTFQKAREY SVKTARLPIQ EYMVRNQNGK NYHSEILAIN QVFDILSTYL ETHNWPEALK KGVSSGKGYI LRNSVE
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