About Kelch-like protein 35
Kelch-like protein 35 (KLHL35) is a protein
from Homo sapiens identified by UniProt accession
Q6PF15, 583 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Kelch-like protein 35 |
|---|
| UniProt accession | Q6PF15 |
|---|
| Gene | KLHL35 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 583 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- lymphocyte percentage of leukocytes · score 0.16
- coronary artery disease · score 0.10
- lymphocyte count · score 0.07
- C-X-C motif chemokine 16 measurement · score 0.03
- colorectal adenocarcinoma · score 0.02
- high density lipoprotein cholesterol measurement · score 0.02
- colorectal cancer · score 0.01
- Colon Sessile Serrated Adenoma/Polyp · score 0.00
- melanoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PF15-F1 | alphafold | PREDICTED | 89.31 | — |
Amino-acid sequence (583 residues)
MRQGHAPEES EPGCEAPCAG PCHAQRVLQA LNAYRRSGTL TDVVLRAGGR DFPCHRAALS AGSAYFRSLF AAGRPERGPA VVPVVPVAPE APGTSPAGAA AALAVVLDYV YGAGVRLRAE DEAAAVLALA ERLGVAGLRE ACVRFLEGRL RAANSLALRR VAAAFSLAPL AERCGRVLRQ AFAEVARHAD FLELAPDEVV ALLADPALGV AREEAVFEAA MRWVRHDAPA RRGQLRRLLE HVRLPLLAPA YFLEKVEADE LLQACGECRP LLLEARACFI LGREAGALRT RPRRFMDLAE VIVVIGGCDR KGLLKLPFAD AYHPESQRWT PLPSLPGYTR SEFAACALRN DVYVSGGHIN SHDVWMFSSH LHTWIKVASL HKGRWRHKMA VVQGQLFAVG GFDGLRRLHS VERYDPFSNT WAAAAPLPEA VSSAAVASCA GKLFVIGGAR QGGVNTDKVQ CFDPKEDRWS LRSPAPFSQR CLEAVSLEDT IYVMGGLMSK IFTYDPGTDV WGEAAVLPSP VESCGVTVCD GKVHILGGRD DRGESTDKVF TFDPSSGQVE VQPSLQRCTS SHGCVTIIQS LGR
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