About Cilia- and flagella-associated protein HOATZ
Cilia- and flagella-associated protein HOATZ (HOATZ) is a protein
from Homo sapiens identified by UniProt accession
Q6PI97, 169 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein HOATZ |
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| UniProt accession | Q6PI97 |
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| Gene | HOATZ |
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| Organism | Homo sapiens |
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| Length | 169 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (93)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- protein measurement · score 0.08
- heel bone mineral density · score 0.07
- spermatogenic failure 51 · score 0.07
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 42 · score 0.07
- spermatogenic failure, X-linked, 3 · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- spermatogenic failure 46 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PI97-F1 | alphafold | PREDICTED | 73.80 | — |
Amino-acid sequence (169 residues)
METGPSEEPS GRKESQEMCP PGLLVFAGSS EQDANLAKQF WISASMYPPS ESQLVLRRDS SQRLPVARPR RSRGSENSHS SQSFHLASNK NRDIFAEALK IQESEEKVKY LQKAKTREEI LQLLRKQREE RISKELISLP YKPKAKEHKA KKVVSESDKE DQEEVKTLD
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