Kelch domain-containing protein 10 (KLHDC10)

About Kelch domain-containing protein 10

Kelch domain-containing protein 10 (KLHDC10) is a protein from Homo sapiens identified by UniProt accession Q6PID8, 442 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

Target properties

Protein name	Kelch domain-containing protein 10
UniProt accession	Q6PID8
Gene	KLHDC10
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.38
low density lipoprotein cholesterol measurement · score 0.23
brain measurement · score 0.16
coronary artery disease · score 0.05
hair color · score 0.05
MODY · score 0.05
platelet count · score 0.05
Red cell distribution width · score 0.04
metabolite measurement · score 0.04
sex hormone-binding globulin measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6PID8-F1	alphafold	PREDICTED	84.50	—

Amino-acid sequence (442 residues)

MSAAQGWDRN RRRGGGAAGA GGGGSGAGGG SGGSGGRGTG QLNRFVQLSG RPHLPGKKKI RWDPVRRRFI QSCPIIRIPN RFLRGHRPPP ARSGHRCVAD NTNLYVFGGY NPDYDESGGP DNEDYPLFRE LWRYHFATGV WHQMGTDGYM PRELASMSLV LHGNNLLVFG GTGIPFGESN GNDVHVCNVK YKRWALLSCR GKKPSRIYGQ AMAIINGSLY VFGGTTGYIY STDLHKLDLN TREWTQLKPN NLSCDLPEER YRHEIAHDGQ RIYILGGGTS WTAYSLNKIH AYNLETNAWE EIATKPHEKI GFPAARRCHS CVQIKNDVFI CGGYNGEVIL GDIWKLNLQT FQWVKLPATM PEPVYFHCAA VTPAGCMYIH GGVVNIHENK RTGSLFKIWL VVPSLLELAW EKLLAAFPNL ANLSRTQLLH LGLTQGLIER LK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards