Hydroxyacylglutathione hydrolase-like protein (HAGHL)

About Hydroxyacylglutathione hydrolase-like protein

Hydroxyacylglutathione hydrolase-like protein (HAGHL) is a protein from Homo sapiens identified by UniProt accession Q6PII5, 290 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Hydroxyacylglutathione hydrolase-like protein
UniProt accession	Q6PII5
Gene	HAGHL
Organism	Homo sapiens
Length	290 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

body height · score 0.27
lean body mass · score 0.25
appendicular lean mass · score 0.20
BMI-adjusted hip circumference · score 0.19
bone fracture · score 0.18
body weight · score 0.17
forced expiratory volume · score 0.16
fat body mass · score 0.16
vital capacity · score 0.14
sitting height measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6PII5-F1	alphafold	PREDICTED	76.24	—

Amino-acid sequence (290 residues)

MKVKVIPVLE DNYMYLVIEE LTREAVAVDV AVPKRLLEIV GREGVSLTAV LTTHHHWDHA RGNPELARLR PGLAVLGADE RIFSLTRRLA HGEELRFGAI HVRCLLTPGH TAGHMSYFLW EDDCPDPPAL FSGDALSVAG CGSCLEGSAQ QMYQSLAELG TLPPETKVFC GHEHTLSNLE FAQKVEPCND HVRAKLSWAK ARPLSRRGKR VGGEGTGFGV GGALRQGLMV TGACGHSRRG MRMTCPLCRR LWARSASTTP SCGWREYGCC PGASTVTWTL RKASGDCVLG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards