About Forkhead box protein R1
Forkhead box protein R1 (FOXR1) is a protein
from Homo sapiens identified by UniProt accession
Q6PIV2, 292 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Forkhead box protein R1 |
|---|
| UniProt accession | Q6PIV2 |
|---|
| Gene | FOXR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 292 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (86)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.19
- urinary bladder carcinoma · score 0.19
- Microcephaly · score 0.19
- Global developmental delay · score 0.19
- acute myeloid leukemia · score 0.19
- breast carcinoma · score 0.18
- gastric adenocarcinoma · score 0.18
- colorectal adenocarcinoma · score 0.18
- gastric carcinoma · score 0.18
- clear cell renal carcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PIV2-F1 | alphafold | PREDICTED | 66.30 | — |
Amino-acid sequence (292 residues)
MGNELFLAFT TSHLPLAEQK LARYKLRIVK PPKLPLEKKP NPDKDGPDYE PNLWMWVNPN IVYPPGKLEV SGRRKREDLT STLPSSQPPQ KEEDASCSEA AGVESLSQSS SKRSPPRKRF AFSPSTWELT EEEEAEDQED SSSMALPSPH KRAPLQSRRL RQASSQAGRL WSRPPLNYFH LIALALRNSS PCGLNVQQIY SFTRKHFPFF RTAPEGWKNT VRHNLCFRDS FEKVPVSMQG GASTRPRSCL WKLTEEGHRR FAEEARALAS TRLESIQQCM SQPDVMPFLF DL
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