Poly(A) RNA polymerase GLD2 (TENT2)

About Poly(A) RNA polymerase GLD2

Poly(A) RNA polymerase GLD2 (TENT2) is a protein from Homo sapiens identified by UniProt accession Q6PIY7, 484 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	Poly(A) RNA polymerase GLD2
UniProt accession	Q6PIY7
Gene	TENT2
Organism	Homo sapiens
Length	484 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

body height · score 0.28
appendicular lean mass · score 0.17
neoplasm · score 0.08
hepatocellular carcinoma · score 0.03
diet measurement · score 0.02
bipolar disorder · score 0.02
attention deficit hyperactivity disorder · score 0.02
juvenile dermatomyositis · score 0.01
hepatitis C virus infection · score 0.01
nonpapillary renal cell carcinoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6PIY7-F1	alphafold	PREDICTED	76.70	—

Amino-acid sequence (484 residues)

MFPNSILGRP PFTPNHQQHN NFFTLSPTVY SHQQLIDAQF NFQNADLSRA VSLQQLTYGN VSPIQTSASP LFRGRKRLSD EKNLPLDGKR QRFHSPHQEP TVVNQIVPLS GERRYSMPPL FHTHYVPDIV RCVPPFREIA FLEPREITLP EAKDKLSQQI LELFETCQQQ ISDLKKKELC RTQLQREIQL LFPQSRLFLV GSSLNGFGTR SSDGDLCLVV KEEPCFFQVN QKTEARHILT LVHKHFCTRL SGYIERPQLI RAKVPIVKFR DKVSCVEFDL NVNNIVGIRN TFLLRTYAYL ENRVRPLVLV IKKWASHHQI NDASRGTLSS YSLVLMVLHY LQTLPEPILP SLQKIYPESF SPAIQLHLVH QAPCNVPPYL SKNESNLGDL LLGFLKYYAT EFDWNSQMIS VREAKAIPRP DGIEWRNKYI CVEEPFDGTN TARAVHEKQK FDMIKDQFLK SWHRLKNKRD LNSILPVRAA VLKR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards