About T-cell receptor-associated transmembrane adapter 1
T-cell receptor-associated transmembrane adapter 1 (TRAT1) is a protein
from Homo sapiens identified by UniProt accession
Q6PIZ9, 186 residues long.
MolForge cross-references it against 0 known binders and
186 disease associations.
Target properties
| Protein name | T-cell receptor-associated transmembrane adapter 1 |
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| UniProt accession | Q6PIZ9 |
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| Gene | TRAT1 |
|---|
| Organism | Homo sapiens |
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| Length | 186 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (186)
Diseases linked to this target (Open Targets).
- cancer · score 0.39
- glioblastoma multiforme · score 0.29
- autoimmune thyroid disease · score 0.29
- breast adenocarcinoma · score 0.29
- Thyroid preparation use measurement · score 0.28
- lung adenocarcinoma · score 0.27
- endometrial cancer · score 0.23
- lymphocyte count · score 0.22
- head and neck squamous cell carcinoma · score 0.19
- hepatocellular carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PIZ9-F1 | alphafold | PREDICTED | 63.77 | — |
Amino-acid sequence (186 residues)
MSGISGCPFF LWGLLALLGL ALVISLIFNI SHYVEKQRQD KMYSYSSDHT RVDEYYIEDT PIYGNLDDMI SEPMDENCYE QMKARPEKSV NKMQEATPSA QATNETQMCY ASLDHSVKGK RRKPRKQNTH FSDKDGDEQL HAIDASVSKT TLVDSFSPES QAVEENIHDD PIRLFGLIRA KREPIN
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