E3 ubiquitin-protein ligase TRIM65 (TRIM65)

About E3 ubiquitin-protein ligase TRIM65

E3 ubiquitin-protein ligase TRIM65 (TRIM65) is a protein from Homo sapiens identified by UniProt accession Q6PJ69, 517 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase TRIM65
UniProt accession	Q6PJ69
Gene	TRIM65
Organism	Homo sapiens
Length	517 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

white matter hyperintensity measurement · score 0.30
low density lipoprotein cholesterol measurement · score 0.22
brain measurement · score 0.20
body fat percentage · score 0.19
body mass index · score 0.18
mean corpuscular volume · score 0.18
pulse pressure measurement · score 0.18
fat body mass · score 0.17
hypertension · score 0.16
erythrocyte count · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6PJ69-F1	alphafold	PREDICTED	84.01	—

Amino-acid sequence (517 residues)

MAAQLLEEKL TCAICLGLYQ DPVTLPCGHN FCGACIRDWW DRCGKACPEC REPFPDGAEL RRNVALSGVL EVVRAGPARD PGPDPGPGPD PAARCPRHGR PLELFCRTEG RCVCSVCTVR ECRLHERALL DAERLKREAQ LRASLEVTQQ QATQAEGQLL ELRKQSSQIQ NSACILASWV SGKFSSLLQA LEIQHTTALR SIEVAKTQAL AQARDEEQRL RVHLEAVARH GCRIRELLEQ VDEQTFLQES QLLQPPGPLG PLTPLQWDED QQLGDLKQLL SRLCGLLLEE GSHPGAPAKP VDLAPVEAPG PLAPVPSTVC PLRRKLWQNY RNLTFDPVSA NRHFYLSRQD QQVKHCRQSR GPGGPGSFEL WQVQCAQSFQ AGHHYWEVRA SDHSVTLGVS YPQLPRCRLG PHTDNIGRGP CSWGLCVQED SLQAWHNGEA QRLPGVSGRL LGMDLDLASG CLTFYSLEPQ TQPLYTFHAL FNQPLTPVFW LLEGRTLTLC HQPGAVFPLG PQEEVLS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards