About Proton-coupled zinc antiporter SLC30A9, mitochondrial
Proton-coupled zinc antiporter SLC30A9, mitochondrial (SLC30A9) is a protein
from Homo sapiens identified by UniProt accession
Q6PML9, 568 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Proton-coupled zinc antiporter SLC30A9, mitochondrial |
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| UniProt accession | Q6PML9 |
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| Gene | SLC30A9 |
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| Organism | Homo sapiens |
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| Length | 568 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- psychomotor regression-oculomotor apraxia-movement disorder-nephropathy syndrome · score 0.68
- neurodegenerative disease · score 0.41
- unipolar depression · score 0.32
- bipolar disorder · score 0.28
- autism spectrum disorder · score 0.24
- schizophrenia · score 0.23
- attention deficit hyperactivity disorder · score 0.23
- obsessive-compulsive disorder · score 0.23
- Tourette syndrome · score 0.23
- anorexia nervosa · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6PML9-F1 | alphafold | PREDICTED | 74.93 | — |
Amino-acid sequence (568 residues)
MLPGLAAAAA HRCSWSSLCR LRLRCRAAAC NPSDRQEWQN LVTFGSFSNM VPCSHPYIGT LSQVKLYSTN VQKEGQGSQT LRVEKVPSFE TAEGIGTELK APLKQEPLQV RVKAVLKKRE YGSKYTQNNF ITGVRAINEF CLKSSDLEQL RKIRRRSPHE DTESFTVYLR SDVEAKSLEV WGSPEALARE KKLRKEAEIE YRERLFRNQK ILREYRDFLG NTKPRSRTAS VFFKGPGKVV MVAICINGLN CFFKFLAWIY TGSASMFSEA IHSLSDTCNQ GLLALGISKS VQTPDPSHPY GFSNMRYISS LISGVGIFMM GAGLSWYHGV MGLLHPQPIE SLLWAYCILA GSLVSEGATL LVAVNELRRN ARAKGMSFYK YVMESRDPST NVILLEDTAA VLGVIIAATC MGLTSITGNP LYDSLGSLGV GTLLGMVSAF LIYTNTEALL GRSIQPEQVQ RLTELLENDP SVRAIHDVKA TDLGLGKVRF KAEVDFDGRV VTRSYLEKQD FDQMLQEIQE VKTPEELETF MLKHGENIID TLGAEVDRLE KELKKRNPEV RHVDLEIL
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