WD repeat-containing protein 74 (WDR74)

About WD repeat-containing protein 74

WD repeat-containing protein 74 (WDR74) is a protein from Homo sapiens identified by UniProt accession Q6RFH5, 385 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	WD repeat-containing protein 74
UniProt accession	Q6RFH5
Gene	WDR74
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

cancer · score 0.06
neoplasm · score 0.05
hepatocellular carcinoma · score 0.03
non-small cell lung carcinoma · score 0.02
melanoma · score 0.02
adrenal cortex carcinoma · score 0.01
diabetic foot · score 0.01
lung adenocarcinoma · score 0.01
cutaneous melanoma · score 0.01
breast cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6RFH5-F1	alphafold	PREDICTED	83.28	—

Amino-acid sequence (385 residues)

MAAAAARWNH VWVGTETGIL KGVNLQRKQA ANFTAGGQPR REEAVSALCW GTGGETQMLV GCADRTVKHF STEDGIFQGQ RHCPGGEGMF RGLAQADGTL ITCVDSGILR VWHDKDKDTS SDPLLELRVG PGVCRMRQDP AHPHVVATGG KENALKIWDL QGSEEPVFRA KNVRNDWLDL RVPIWDQDIQ FLPGSQKLVT CTGYHQVRVY DPASPQRRPV LETTYGEYPL TAMTLTPGGN SVIVGNTHGQ LAEIDLRQGR LLGCLKGLAG SVRGLQCHPS KPLLASCGLD RVLRIHRIQN PRGLEHKVYL KSQLNCLLLS GRDNWEDEPQ EPQEPNKVPL EDTETDELWA SLEAAAKRKL SGLEQPQGAL QTRRRKKKRP GSTSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards