Type-1 angiotensin II receptor-associated protein…

About Type-1 angiotensin II receptor-associated protein

Type-1 angiotensin II receptor-associated protein (AGTRAP) is a protein from Homo sapiens identified by UniProt accession Q6RW13, 159 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.

Target properties

Protein name	Type-1 angiotensin II receptor-associated protein
UniProt accession	Q6RW13
Gene	AGTRAP
Organism	Homo sapiens
Length	159 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (161)

Diseases linked to this target (Open Targets).

cancer · score 0.56
basophil percentage of leukocytes · score 0.20
basophil count · score 0.15
endometrial cancer · score 0.09
hepatocellular carcinoma · score 0.09
non-alcoholic fatty liver disease · score 0.07
Blackfan-Diamond anemia · score 0.07
IGA glomerulonephritis · score 0.06
metabolic disease · score 0.06
focal segmental glomerulosclerosis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6RW13-F1	alphafold	PREDICTED	80.58	—

Amino-acid sequence (159 residues)

MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS IDAISMFLGG LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP LSCCFVYHMY RERGGELLVH TGFLGSSQDR SAYQTIDSAE APADPFAVPE GRSQDARGY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Type-1 angiotensin II receptor-associated protein (AGTRAP)