About Testis-specific serine/threonine-protein kinase 4
Testis-specific serine/threonine-protein kinase 4 (TSSK4) is a protein
from Homo sapiens identified by UniProt accession
Q6SA08, 328 residues long.
MolForge cross-references it against 0 known binders and
91 disease associations.
Target properties
| Protein name | Testis-specific serine/threonine-protein kinase 4 |
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| UniProt accession | Q6SA08 |
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| Gene | TSSK4 |
|---|
| Organism | Homo sapiens |
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| Length | 328 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (91)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 72 · score 0.06
- spermatogenic failure 46 · score 0.06
- spermatogenic failure 27 · score 0.06
- spermatogenic failure 18 · score 0.06
- spermatogenic failure 65 · score 0.06
- spermatogenic failure 49 · score 0.06
- spermatogenic failure 43 · score 0.06
- spermatogenic failure 45 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6SA08-F1 | alphafold | PREDICTED | 86.32 | — |
Amino-acid sequence (328 residues)
MGKGDVLEAA PTTTAYHSLM DEYGYEVGKA IGHGSYGSVY EAFYTKQKVM VAVKIISKKK ASDDYLNKFL PREIQVMKVL RHKYLINFYR AIESTSRVYI ILELAQGGDV LEWIQRYGAC SEPLAGKWFS QLTLGIAYLH SKSIVHRDLK LENLLLDKWE NVKISDFGFA KMVPSNQPVG CSPSYRQVNC FSHLSQTYCG SFAYACPEIL RGLPYNPFLS DTWSMGVILY TLVVAHLPFD DTNLKKLLRE TQKEVTFPAN HTISQECKNL ILQMLRQATK RATILDIIKD SWVLKFQPEQ PTHEIRLLEA MCQLHNTTKQ HQSLQITT
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