About SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (SMARCD3) is a protein
from Homo sapiens identified by UniProt accession
Q6STE5, 483 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 |
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| UniProt accession | Q6STE5 |
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| Gene | SMARCD3 |
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| Organism | Homo sapiens |
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| Length | 483 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (116)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.28
- breast adenocarcinoma · score 0.24
- BMI-adjusted waist circumference · score 0.23
- bone density · score 0.20
- hemoglobin measurement · score 0.20
- hematocrit · score 0.20
- multiple myeloma · score 0.20
- clear cell renal carcinoma · score 0.19
- endometrial cancer · score 0.18
- red blood cell density measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6STE5-F1 | alphafold | PREDICTED | 79.51 | — |
Amino-acid sequence (483 residues)
MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY MGSPAVRPGL APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR RKMADKILPQ RIRELVPESQ AYMDLLAFER KLDQTIMRKR VDIQEALKRP MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA SWELRVEGKL LDDPSKQKRK FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV KRPGDLSVRC TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS DQKKTACYDI DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN QLKIQRDFML SFSRDPKGYV QDLLRSQSRD LKVMTDVAGN PEEERRAEFY HQPWSQEAVS RYFYCKIQQR RQELEQSLVV RNT
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