About Kelch-like protein 17
Kelch-like protein 17 (KLHL17) is a protein
from Homo sapiens identified by UniProt accession
Q6TDP4, 642 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Kelch-like protein 17 |
|---|
| UniProt accession | Q6TDP4 |
|---|
| Gene | KLHL17 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 642 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (24)
Diseases linked to this target (Open Targets).
- alkaline phosphatase measurement · score 0.28
- Tracheoesophageal fistula · score 0.26
- heel bone mineral density · score 0.15
- pancreatic carcinoma · score 0.11
- mitochondrial DNA measurement · score 0.10
- atrial fibrillation · score 0.07
- attention deficit hyperactivity disorder · score 0.06
- Asperger syndrome · score 0.06
- non-small cell lung carcinoma · score 0.05
- alcohol consumption measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q6TDP4-F1 | alphafold | PREDICTED | 87.23 | — |
Amino-acid sequence (642 residues)
MQPRSERPAG RTQSPEHGSP GPGPEAPPPP PPQPPAPEAE RTRPRQARPA APMEGAVQLL SREGHSVAHN SKRHYHDAFV AMSRMRQRGL LCDIVLHVAA KEIRAHKVVL ASCSPYFHAM FTNEMSESRQ THVTLHDIDP QALDQLVQFA YTAEIVVGEG NVQTLLPAAS LLQLNGVRDA CCKFLLSQLD PSNCLGIRGF ADAHSCSDLL KAAHRYVLQH FVDVAKTEEF MLLPLKQVLE LVSSDSLNVP SEEEVYRAVL SWVKHDVDAR RQHVPRLMKC VRLPLLSRDF LLGHVDAESL VRHHPDCKDL LIEALKFHLL PEQRGVLGTS RTRPRRCEGA GPVLFAVGGG SLFAIHGDCE AYDTRTDRWH VVASMSTRRA RVGVAAVGNR LYAVGGYDGT SDLATVESYD PVTNTWQPEV SMGTRRSCLG VAALHGLLYS AGGYDGASCL NSAERYDPLT GTWTSVAAMS TRRRYVRVAT LDGNLYAVGG YDSSSHLATV EKYEPQVNVW SPVASMLSRR SSAGVAVLEG ALYVAGGNDG TSCLNSVERY SPKAGAWESV APMNIRRSTH DLVAMDGWLY AVGGNDGSSS LNSIEKYNPR TNKWVAASCM FTRRSSVGVA VLELLNFPPP SSPTLSVSST SL
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